Osteonecrosis of the jaw and the use of antiangiogenic agents: just an association?
نویسندگان
چکیده
Disclosure: The article discusses the use of bevacizumab (Genentech) for prostate cancer and thalidomide (Celgene) for prostate cancer. The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. No financial relationships relevant to the content of this article have been disclosed by the authors, planners, independent peer reviewers, or staff managers.
منابع مشابه
Delayed Diagnosis of Osteonecrosis of the Jaw (ONJ) Associated with Bevacizumab Therapy in Colorectal Cancer Patients: Report of Two Cases
Medication-induced Osteonecrosis of the Jaw (MRONJ) has been reported not only after use of antiresorptive agents (bisphosphonates and denosumab), but also in cancer patients receiving antiangiogenic agents, alone or combined with antiresorptive drugs. We report two cases of MRONJ observed in colorectal cancer patients after bevacizumab therapy only. MRONJ was diagnosed, respectively, two and s...
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Osteonecrosis of the jaw (ONJ) is a common side effect of antiresorptive drugs that are administered to cancer patients for bone metastasis, multiple myeloma, and osteoporosis. Since both bisphosphonate (BP) and denosumab show anti-bone resorption effects with ONJ, antiresorptive agent-related ONJ (ARONJ) has been suggested as a comprehensive term encompassing both BP-related osteonecrosis of t...
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Bisphosphonates are potent and effective drugs frequently used to prevent the skeletal complications associated with postmenopausal osteoporosis in women, to manage patients with multiple myeloma, hypercalcemia, and metastasis of cancer to the bone. The search for new medications with the same therapeutic effectiveness as the bisphosphonates but fewer side effects has resulted in the discovery ...
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Multifocal avascular osteonecrosis is an uncommon entity having a predominant association with steroids and less commonly with alcohol abuse. In literature only few cases of alcohol induced multifocal avascular osteonecrosis involving both hips and shoulder are reported. To the best of our understanding this is the first case report or contribution from nuclear medicine court and it would help ...
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عنوان ژورنال:
- The oncologist
دوره 13 12 شماره
صفحات -
تاریخ انتشار 2008